In nature, the riparian zone is a unique rich ecosystem created through the interaction of a river with its banks. In the human body, moving blood, or hemodynamics, interacts with the walls of blood vessels generating unique biological activity. This unique flow-sensitive biology is a critical and unexplored determinant of vascular health. Riparian’s therapeutic programs target new vasoprotective pathways to hopefully treat both prevalent and serious rare vascular diseases at an earlier stage than is possible today.